Architecture of the human mTORC2 core complex
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.
Date Issued
2018-02-09
Date Acceptance
2018-02-08
Citation
eLife, 2018, 7 (1)
ISSN
2050-084X
Publisher
eLife Sciences Publications Ltd
Journal / Book Title
eLife
Volume
7
Issue
1
Copyright Statement
Copyright © Stuttfeld et al. This
article is distributed under the
terms of the
Creative Commons
Attribution License,
which
permits unrestricted use and
redistribution provided that the
original author and source are
credited (https://creativecommons.org/licenses/by/4.0/)
article is distributed under the
terms of the
Creative Commons
Attribution License,
which
permits unrestricted use and
redistribution provided that the
original author and source are
credited (https://creativecommons.org/licenses/by/4.0/)
Sponsor
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29424687
PII: 33101
Grant Number
206212/Z/17/Z
Subjects
cell growth
electron microscopy
human
molecular biophysics
regulation
structural biology
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN e33101