The accuracy of haemoglobin A2 measurements in the presence and absence of haemoglobin S
Author(s)
Myburgh, Jane K
Szydlo, Richard M
Bain, Barbara J
Type
Journal Article
Abstract
The quantification of haemoglobin A2 by high-performance liquid chromatography (HPLC) was compared with quantification by capillary electrophoresis for control subjects and patients with sickle cell trait or sickle cell anaemia. Significant differences were found, with estimated values being higher by HPLC for control subjects and higher by capillary electrophoresis for sickle cell trait and sickle cell anaemia patients. There is an ongoing need for improved standardisation and alignment of methods.
Date Issued
2023-05
Date Acceptance
2023-04-01
Citation
eJHaem, 2023, 4 (2), pp.437-441
ISSN
2688-6146
Publisher
Wiley
Start Page
437
End Page
441
Journal / Book Title
eJHaem
Volume
4
Issue
2
Copyright Statement
© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37206262
PII: JHA2691
Subjects
capillary electrophoresis
haemoglobin A2
high‐performance liquid chromatography
sickle cell anaemia
sickle cell trait
thalassaemia
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-04-17