Gestational diabetes exposed mesenchymal stem cells: phenotypic differences link to long-term health of offspring
File(s)
Published version
Author(s)
Pandrich, Mark J
Shah, Nishel M
Garcia Perez, Isabel
Johnson, Mark R
Singh, Natasha
Type
Journal Article
Abstract
Mesenchymal stem cells (MSCs) derived from the placenta, fetal membranes, or umbilical cord may be used to study the pathophysiology of gestational diabetes mellitus (GDM). The phenotype of MSCs may reflect fetal programming in response to the maternal milieu of a GDM pregnancy. Altered fetal programming is linked to high rates of obesity and type 2 diabetes mellitus (T2DM) in the offspring of mothers with GDM. This review discusses recent findings characterizing the phenotype of GDM-exposed MSCs (GDM-MSCs) which enhance our understanding of the mechanisms of fetal programming. It also considers how MSCs may be used as markers of long-term offspring health to test the benefit of putative interventions and highlights the need for further translational studies to clearly link the MSC phenotype to clinical parameters and interventions.
Date Issued
2025-11-05
Date Acceptance
2025-11-03
Citation
International Journal of Molecular Sciences, 2025, 26 (21)
ISSN
1422-0067
Publisher
MDPI AG
Start Page
10768
End Page
10768
Journal / Book Title
International Journal of Molecular Sciences
Volume
26
Issue
21
Copyright Statement
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
License URL
Publication Status
Published
Article Number
10768
Date Publish Online
2025-11-05