Update on neutrophil function in severe inflammation
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Published version
Author(s)
Mortaz, Esmaeil
Alipoor, Shamila
Adcock, IM
Mumby, Sharon
Koenderman, Leo
Type
Journal Article
Abstract
Neutrophils are main players in the effector phase of the host defense against
micro-organisms and have a major role in the innate immune response. Neutrophils
show phenotypic heterogeneity and functional flexibility, which highlight their importance
in regulation of immune function. However, neutrophils can play a dual role and besides
their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead
to tissue damage in severe inflammation or trauma. Neutrophils also have an important
role in the modulation of the immune system in response to severe injury and trauma.
In this review we will provide an overview of the current understanding of neutrophil
subpopulations and their function during and post-infection and discuss the possible
mechanisms of immune modulation by neutrophils in severe inflammation.
micro-organisms and have a major role in the innate immune response. Neutrophils
show phenotypic heterogeneity and functional flexibility, which highlight their importance
in regulation of immune function. However, neutrophils can play a dual role and besides
their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead
to tissue damage in severe inflammation or trauma. Neutrophils also have an important
role in the modulation of the immune system in response to severe injury and trauma.
In this review we will provide an overview of the current understanding of neutrophil
subpopulations and their function during and post-infection and discuss the possible
mechanisms of immune modulation by neutrophils in severe inflammation.
Date Issued
2018-10-02
Date Acceptance
2018-09-21
Citation
Frontiers in Immunology, 2018, 9
ISSN
1664-3224
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Immunology
Volume
9
Copyright Statement
© 2018 Mortaz, Alipoor, Adcock, Mumby and Koenderman. This is an
open-access article distributed under the terms of the Creative Commons Attribution
License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) and the copyright owner(s) are credited and that the
original publication in this journal is cited, in accordance with accepted academic
practice. No use, distribution or reproduction is permitted which does not comply
with these terms.
open-access article distributed under the terms of the Creative Commons Attribution
License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) and the copyright owner(s) are credited and that the
original publication in this journal is cited, in accordance with accepted academic
practice. No use, distribution or reproduction is permitted which does not comply
with these terms.
Sponsor
Wellcome Trust
British Heart Foundation
Dunhill Medical Trust
Grant Number
093080/Z/10/Z
PG/14/27/30679
R368/0714
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
neutrophils
infection
CD64
innate immunity
severe inflammation
trauma
EXTRACELLULAR-MATRIX PROTEINS
TUMOR-ASSOCIATED NEUTROPHILS
MULTIPLE ORGAN FAILURE
HUMAN EXPERIMENTAL ENDOTOXEMIA
GR-1(+) MYELOID CELLS
HUMAN LUNG-CANCER
SUPPRESSOR-CELLS
IMMUNE DYSFUNCTION
SERINE PROTEASES
TRAUMA PATIENTS
Publication Status
Published
Article Number
ARTN 2171