Executive summary: the 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis
Author(s)
Type
Journal Article
Abstract
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) are heterogeneous, multisystem disorders characterized by inflammation and necrosis of small and medium-sized blood vessels with unknown aetiology. Three distinct clinico-pathological syndromes have been identified: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) associated with autoantibodies directed against neutrophil granular proteins, proteinase 3 and myeloperoxidase. These conditions are uncommon with incidence and prevalence rates of 25/million population and 200/million, respectively [1]. Despite significant advances in treatment,mortality rates remain elevated, 2.3 times that of the general population [2]. Early diagnosis, instituting appropriate immunosuppression swiftly, and limiting toxicity from treatment is key to mitigating mortality and damage from AAV.
Date Issued
2025-08-01
Date Acceptance
2025-04-24
Citation
Rheumatology, 2025, 64 (8), pp.4463-4469
ISSN
1462-0324
Publisher
Oxford University Press
Start Page
4463
End Page
4469
Journal / Book Title
Rheumatology
Volume
64
Issue
8
Copyright Statement
© The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40499929
PII: 8160139
Subjects
British Society for Rheumatology Guideline Steering Group
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2025-06-12