A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
Author(s)
Type
Journal Article
Abstract
Beyond its role in cellular homeostasis, autophagy plays anti‐ and promicrobial roles in host–microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well‐described in animals, the extent to which xenophagy contributes to plant–bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type‐III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense‐related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense‐related autophagy in plant–bacteria interactions.
Date Issued
2022-07-04
Date Acceptance
2022-04-21
Citation
The EMBO Journal, 2022, 41 (13)
ISSN
0261-4189
Publisher
EMBO Press
Journal / Book Title
The EMBO Journal
Volume
41
Issue
13
Copyright Statement
© 2022 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000800471300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
autophagy
Biochemistry & Molecular Biology
Cell Biology
effectors
immunity
IMMUNITY
Life Sciences & Biomedicine
PHYTOPATHOGEN EFFECTORS
PROTEASOME
PROTEIN
RECOGNITION
RESISTANCE
Science & Technology
SELECTIVE AUTOPHAGY
TRANSCRIPTION
UBIQUITIN
ubiquitination
XANTHOMONAS
xenophagy
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN e110352
Date Publish Online
2022-05-27