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Heart failure with preserved ejection fraction.
File(s)
Author(s)
ElGuindy, A
Yacoub, MH
Type
Journal Article
Abstract
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as a major cause of cardiovascular morbidity and mortality. Contrary to initial beliefs, HFpEF is now known to be as common as heart failure with reduced ejection fraction (HFrEF) and carries an unacceptably high mortality rate. With a prevalence that has been steadily rising over the past two decades, it is very likely that HFpEF will represent the dominant heart failure phenotype over the coming few years. The scarcity of trials in this semi-discrete form of heart failure and lack of unified enrolment criteria in the studies conducted to date might have contributed to the current absence of specific therapies. Understanding the epidemiological, pathophysiological and molecular differences (and similarities) between these two forms of heart failure is cornerstone to the development of targeted therapies. Carefully designed studies that adhere to unified diagnostic criteria with the recruitment of appropriate controls and adoption of practical end-points are urgently needed to help identify effective treatment strategies.
Date Issued
2012-07-17
Date Acceptance
2012-06-13
Citation
Global Cardiology Science and Practice, 2012, 2012 (1), pp.10-10
URI
DOI
ISSN
2305-7823
Publisher
Bloomsbury Qatar Foundation Journals
Start Page
10
End Page
10
Journal / Book Title
Global Cardiology Science and Practice
Volume
2012
Issue
1
Copyright Statement
© 2012 ElGuindy and Yacoub,
licensee Bloomsbury Qatar
Foundation Journals. This is an
open access article distributed
under the terms of the Creative
Commons
Attribution-NonCommercial license
CC BY-NC 3.0 which permits
unrestricted non-commercial use,
distribution and reproduction in
any medium, provided the original
work is properly cited.
License URL
Identifier
PII: gcsp.2012.10
Subjects
diastolic heart failure
heart failure
heart failure with preserved ejection fraction
Publication Status
Published
Article Number
10