Gastro-oesophageal reflux disease outcomes following roux-en-y gastric bypass surgery in patients with obesity: a systematic review and meta-analysis
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB for obesity (January 2000–November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0–59.0; p ≤ 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7–7.2; p ≤ 0.005) with worsening/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2–32.7; p ≤ 0.005) and 79.4% (95% CI 68.7–90.1; p = 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.
Date Issued
2025-06-01
Date Acceptance
2025-04-06
Citation
Obesity Surgery, 2025, 35 (6), pp.2321-2332
ISSN
0960-8923
Publisher
Springer Science and Business Media LLC
Start Page
2321
End Page
2332
Journal / Book Title
Obesity Surgery
Volume
35
Issue
6
Copyright Statement
© The Author(s) 2025 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40272754
PII: 10.1007/s11695-025-07865-x
Subjects
Bariatric surgery
Gastric bypass
Gastro-oesophageal reflux disease
Obesity
Outcomes
Humans
Gastroesophageal Reflux
Gastric Bypass
Treatment Outcome
Obesity, Morbid
Proton Pump Inhibitors
Obesity
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2025-04-24