Trends in peripheral arterial disease incidence and mortality in EU15+ countries 1990-2017.
File(s)
Accepted version
Author(s)
Goodall, Richard
Salciccioli, Justin D
Davies, Alun Huw
Marshall, Dominic
Shalhoub, Joseph
Type
Journal Article
Abstract
AIMS: The aim was to assess trends in peripheral arterial disease (PAD) incidence and mortality rates in European Union(15+) countries between 1990 and 2017. METHODS AND RESULTS: This observational study used data obtained from the 2017 Global Burden of Disease study. Age-standardised mortality and incidence rates from PAD were extracted from the Global Health Data Exchange for EU15+ countries for the years 1990-2017. Trends were analysed using Joinpoint regression analysis. Between 1990 and 2017, the incidence of PAD decreased in all 19 EU15+ countries for females, and in 18 of 19 countries for males. Increasing PAD incidence was observed only for males in the United States (+1.4%). In 2017, the highest incidence rates were observed in Denmark and the United States for males (213.6 and 202.3 per 100,000, respectively) and in the United States and Canada for females (194.8 and 171.1 per 100,000, respectively). There was a concomitant overall trend for increasing age-standardised mortality rates in all EU15+ countries for females, and in 16 of 19 EU15+ countries for males between 1990 and 2017. Italy (-25.1%), Portugal (-1.9%) and Sweden (-0.6%) were the only countries with reducing PAD mortality rates in males. The largest increases in mortality rates were observed in the United Kingdom (males +140.4%, females +158.0%) and the United States (males +125.7%, females +131.2%). CONCLUSIONS: We identify shifting burden of PAD in EU15+ countries, with increasing mortality rates despite reducing incidence. Strong evidence supports goal-directed medical therapy in reducing PAD mortality - population-wide strategies to improve compliance to optimal goal-directed medical therapy are warranted.
Date Issued
2021-11
Date Acceptance
2019-12-17
Citation
European Journal of Preventive Cardiology, 2021, 28 (11), pp.1201-1213
ISSN
2047-4873
Publisher
SAGE Publications
Start Page
1201
End Page
1213
Journal / Book Title
European Journal of Preventive Cardiology
Volume
28
Issue
11
Copyright Statement
© The European Society of
Cardiology 2020
Article reuse guidelines:
sagepub.com/journals-permissions. The final, definitive version of this paper has been published in Goodall, R., Salciccioli, J. D., Davies, A. H., Marshall, D., & Shalhoub, J. (2020). Trends in peripheral arterial disease incidence and mortality in EU15+ countries 1990–2017. European Journal of Preventive Cardiology by Sage Publications Ltd. All rights reserved. It is available at: https://doi.org/10.1177/2047487319899626
Cardiology 2020
Article reuse guidelines:
sagepub.com/journals-permissions. The final, definitive version of this paper has been published in Goodall, R., Salciccioli, J. D., Davies, A. H., Marshall, D., & Shalhoub, J. (2020). Trends in peripheral arterial disease incidence and mortality in EU15+ countries 1990–2017. European Journal of Preventive Cardiology by Sage Publications Ltd. All rights reserved. It is available at: https://doi.org/10.1177/2047487319899626
Sponsor
National Institute for Health Research
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32013595
Grant Number
NIHR201345
Subjects
Incidence
mortality
peripheral arterial disease
secondary prevention
trends
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-02-03