BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms.
File(s)
Published version
Author(s)
Riangrungroj, Pinpunya
Polizzi, Karen M
Type
Journal Article
Abstract
This opinion piece describes a new design for the remediation of recalcitrant biofilms. It builds on previous work to develop engineered E. coli that recognize quorum sensing signals from pathogens in a biofilm and secrete toxins in response. To solve the challenge of dilute signalling molecules, we propose to use nanobodies and enzymes displayed on the surface of the cells to localize them to the biofilm and degrade the extracellular polymeric substances, thus creating a solution with better 'seek and destroy' capabilities.
Date Issued
2020-03
Date Acceptance
2019-07-05
Citation
Microbial Biotechnology, 2020, 13 (2), pp.311-314
ISSN
1751-7915
Publisher
Wiley
Start Page
311
End Page
314
Journal / Book Title
Microbial Biotechnology
Volume
13
Issue
2
Copyright Statement
© 2019 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and
reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and
reproduction in any medium, provided the original work is properly cited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31328393
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Microbiology
SINGLE-DOMAIN ANTIBODIES
NANOBODIES
COLI
DISPLAY
ENZYMES
SURFACE
ACID
0605 Microbiology
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2019-07-21