Roles of steroid receptors in the lung and COVID-19
File(s)
Published version
Author(s)
Leach, Damien A
Brooke, Greg N
Bevan, Charlotte L
Type
Journal Article
Abstract
COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) for infection of lung epithelia. The expression and function of the steroid hormone receptor family is important in many aspects that impact on COVID-19 effects in the lung – notably lung development and function, the immune system, and expression of TMPRSS2 and ACE2. This review provides a brief summary of current knowledge on the roles of the steroid hormone receptors [androgen receptor (AR), glucocorticoid receptor (GR), progesterone receptor (PR), mineralocorticoid receptor (MR) and oestrogen receptor (ER)] in the lung, their effects on host cell proteins that facilitate SARS-CoV-2 uptake, and provides a snapshot of current clinical trials investigating the use of steroid receptor (SR) ligands to treat COVID-19.
Editor(s)
Williams, C
Bondesson, M
Frigo, DE
Date Issued
2021-11-26
Date Acceptance
2021-06-23
Citation
Essays in Biochemistry, 2021, 65 (6), pp.1025-1038
ISSN
0071-1365
Publisher
Portland Press
Start Page
1025
End Page
1038
Journal / Book Title
Essays in Biochemistry
Volume
65
Issue
6
Copyright Statement
© 2021 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons
Attribution License 4.0 (CC BY).
Attribution License 4.0 (CC BY).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000726353600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Biochemistry & Molecular Biology
Medicine, Research & Experimental
Research & Experimental Medicine
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
SURFACTANT-PROTEIN-A
CONVERTING ENZYME 2
MINERALOCORTICOID RECEPTOR
FETAL LUNG
PULMONARY SURFACTANT
SARS-COV-2 RECEPTOR
SEXUAL-DIMORPHISM
GENE-EXPRESSION
GLUCOCORTICOID REGULATION
Publication Status
Published
Date Publish Online
2021-11-26