Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
The association between
H. pylori
infection and pancreatic cancer risk remains contro
versial.
We conducted a nested case-control study with 448 p
ancreatic cancer cases and their
individually matched control subjects, based on the
European Prospective Investigation into
Cancer and Nutrition (EPIC) cohort, to determine wh
ether there was an altered pancreatic
cancer risk associated with
H. pylori
infection and chronic corpus atrophic gastritis.
Conditional logistic regression models were applied
to calculate odds ratios (ORs) and
corresponding 95% confidence intervals (CIs), adjus
ted for matching factors and other
potential confounders. Our results showed that panc
reatic cancer risk was neither
associated with
H. pylori
seropositivity (OR=0.96; 95% CI: 0.70, 1.31) nor C
agA seropositivity
(OR=1.07; 95% CI: 0.77, 1.48). We also did not find
any excess risk among individuals
seropositive for
H. pylori
but seronegative for CagA, compared with the group
seronegative
for both antibodies (OR=0.94; 95% CI: 0.63, 1.38).
However, we found that chronic corpus
atrophic gastritis was non-significantly associated
with an increased pancreatic cancer risk
(OR=1.35; 95% CI: 0.77, 2.37), and although based o
n small numbers, the excess risk was
particularly marked among individuals seronegative
for both
H. pylori
and CagA (OR=5.66; 95%
CI: 1.59, 20.19,
p
value for interaction < 0.01). Our findings provid
ed evidence supporting the
null association between
H. pylori
infection and pancreatic cancer risk in western Eur
opean
populations. However, the suggested association bet
ween chronic corpus atrophic gastritis
and pancreatic cancer risk warrants independent ver
ification in future studies, and, if
confirmed, further studies on the underlying mechan
isms.
H. pylori
infection and pancreatic cancer risk remains contro
versial.
We conducted a nested case-control study with 448 p
ancreatic cancer cases and their
individually matched control subjects, based on the
European Prospective Investigation into
Cancer and Nutrition (EPIC) cohort, to determine wh
ether there was an altered pancreatic
cancer risk associated with
H. pylori
infection and chronic corpus atrophic gastritis.
Conditional logistic regression models were applied
to calculate odds ratios (ORs) and
corresponding 95% confidence intervals (CIs), adjus
ted for matching factors and other
potential confounders. Our results showed that panc
reatic cancer risk was neither
associated with
H. pylori
seropositivity (OR=0.96; 95% CI: 0.70, 1.31) nor C
agA seropositivity
(OR=1.07; 95% CI: 0.77, 1.48). We also did not find
any excess risk among individuals
seropositive for
H. pylori
but seronegative for CagA, compared with the group
seronegative
for both antibodies (OR=0.94; 95% CI: 0.63, 1.38).
However, we found that chronic corpus
atrophic gastritis was non-significantly associated
with an increased pancreatic cancer risk
(OR=1.35; 95% CI: 0.77, 2.37), and although based o
n small numbers, the excess risk was
particularly marked among individuals seronegative
for both
H. pylori
and CagA (OR=5.66; 95%
CI: 1.59, 20.19,
p
value for interaction < 0.01). Our findings provid
ed evidence supporting the
null association between
H. pylori
infection and pancreatic cancer risk in western Eur
opean
populations. However, the suggested association bet
ween chronic corpus atrophic gastritis
and pancreatic cancer risk warrants independent ver
ification in future studies, and, if
confirmed, further studies on the underlying mechan
isms.
Date Issued
2016-12-29
Date Acceptance
2016-11-22
Citation
International Journal of Cancer, 2016, 140 (8), pp.1727-1735
ISSN
1097-0215
Publisher
Wiley
Start Page
1727
End Page
1735
Journal / Book Title
International Journal of Cancer
Volume
140
Issue
8
Copyright Statement
© 2016 UICC. This is the accepted version of the following article, which has been published in final form at http://dx.doi.org/10.1002/ijc.30590
Sponsor
University Medical Center Utrecht
Imperial College Trust
Grant Number
N/A
P47328
Subjects
EPIC cohort
H. pylori infection
chronic corpus atrophic gastritis
nested case-control study
pancreatic cancer risk
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status
Published