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Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
File(s)
s41467-019-10900-y.pdf (1.04 MB)
Published version
OA Location
Author(s)
Viant, Mark R
Ebbels, Timothy MD
Beger, Richard D
Ekman, Drew R
Epps, David JT
Type
Journal Article
Abstract
Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.
Date Issued
2019-07-10
Date Acceptance
2019-06-07
Citation
Nature Communications, 2019, 10
URI
DOI
ISSN
2041-1723
Publisher
Nature Research (part of Springer Nature)
Journal / Book Title
Nature Communications
Volume
10
Copyright Statement
© 2019 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31292445
PII: 10.1038/s41467-019-10900-y
Subjects
MD Multidisciplinary
Publication Status
Published
Coverage Spatial
England
Article Number
3041