Morphogen gradient formation in partially absorbing media
File(s)absorptionR.pdf (352.32 KB)
Accepted version
Author(s)
Bressloff, Paul C
Type
Journal Article
Abstract
Morphogen gradients play an essential role in the spatial regulation of cell patterning during early development. The classical mechanism of morphogen gradient formation involves the diffusion of morphogens away from a localized source combined with some form of bulk absorption. Morphogen gradient formation plays a crucial role during early development, whereby a spatially varying concentration of morphogen protein drives a corresponding spatial variation in gene expression during embryogenesis. In most models, the absorption rate is taken to be a constant multiple of the local concentration. In this paper, we explore a more general class of diffusion-based model in which absorption is formulated probabilistically in terms of a stopping time condition. Absorption of each particle occurs when its time spent within the bulk domain (occupation time) exceeds a randomly distributed threshold a; the classical model with a constant rate of absorption is recovered by taking the threshold distribution ${\Psi}(a)={\mathrm{e}}^{-{\kappa }_{0}a}$. We explore how the choice of Ψ(a) affects the steady-state concentration gradient, and the relaxation to steady-state as determined by the accumulation time. In particular, we show that the more general model can generate similar concentration profiles to the classical case, while significantly reducing the accumulation time.
Date Issued
2022-11-01
Date Acceptance
2022-09-28
Citation
Physical Biology, 2022, 19 (6)
ISSN
1478-3967
Publisher
IOP Publishing
Journal / Book Title
Physical Biology
Volume
19
Issue
6
Copyright Statement
Copyright © 2022 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article published in Physical Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at 10.1088/1478-3975/ac95ea
Identifier
http://dx.doi.org/10.1088/1478-3975/ac95ea
Publication Status
Published
Article Number
066005
Date Publish Online
2022-10-25