Negative results in phase III trials of complex interventions: cause for concern or just good science?
File(s)Editorial 09 12 15.docx (53.31 KB)
Accepted version
Author(s)
Crawford, MJ
Barnicot, K
Patterson, S
Gold, C
Type
Journal Article
Abstract
Some phase III trials inevitably fail to replicate benefits of interventions seen in earlier smaller-scale studies. But the high failure rate in recent mental health trials is of concern. Proper consideration of trial processes and greater use of adaptive trial designs could ensure better use of available resources.
Date Issued
2016-07-01
Date Acceptance
2016-03-08
Citation
British Journal of Psychiatry, 2016, 209 (1), pp.6-8
ISSN
1472-1465
Publisher
Royal College of Psychiatrists
Start Page
6
End Page
8
Journal / Book Title
British Journal of Psychiatry
Volume
209
Issue
1
Copyright Statement
© 2016 Royal College of Psychiatrists
Sponsor
Department of Health
National Institute for Health Research
Grant Number
04/39/04
PDF-2013-06-054
Subjects
Psychiatry
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status
Published