Animal models of glucocorticoid-induced glaucoma
File(s)AnimalModelsGCGlaucoma-FINAL.docx (141.8 KB)
Accepted version
Author(s)
Overby, DR
Clark, AF
Type
Journal Article
Abstract
Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions.
While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often
associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic
open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different
species besides man. These models mimic many features of this condition in man and provide
morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many
clinical, morphological, and molecular similarities between GC-induced glaucoma and primary openangle
glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models
in which to study specific aspects of POAG.
While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often
associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic
open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different
species besides man. These models mimic many features of this condition in man and provide
morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many
clinical, morphological, and molecular similarities between GC-induced glaucoma and primary openangle
glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models
in which to study specific aspects of POAG.
Date Issued
2015-06-04
Date Acceptance
2015-06-03
Citation
Experimental Eye Research, 2015, 141, pp.15-22
ISSN
0014-4835
Publisher
Elsevier
Start Page
15
End Page
22
Journal / Book Title
Experimental Eye Research
Volume
141
Copyright Statement
© 2015 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364440500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Ophthalmology
Glucocorticoid
Ocular hypertension
Glaucoma
Intraocular pressure
Steroid glaucoma
INDUCED OCULAR HYPERTENSION
TRABECULAR MESHWORK CELLS
LINKED ACTIN NETWORKS
TISSUE-PLASMINOGEN ACTIVATOR
STEROID-INDUCED GLAUCOMA
AQUEOUS-HUMOR DYNAMICS
I COLLAGEN MUTATION
OPEN-ANGLE GLAUCOMA
INTRAOCULAR-PRESSURE
OUTFLOW FACILITY
Animals
Disease Models, Animal
Glucocorticoids
Intraocular Pressure
1101 Medical Biochemistry And Metabolomics
1109 Neurosciences
1113 Ophthalmology And Optometry
Ophthalmology & Optometry
Publication Status
Published