Maternal immunisation has the potential to substantially reduce morbidity and mortality from infectious diseases
after birth. The success of tetanus, influenza, and pertussis immunisation during pregnancy has led to consideration
of additional maternal immunisation strategies to prevent group B streptococcus and respiratory syncytial virus
infections, among others. However, many gaps in knowledge regarding the immunobiology of maternal immunisation
prevent the optimal design and application of this successful public health intervention. Therefore, we did an
innovative landscape analysis to identify research priorities. Key topics were delineated through review of the
published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop that
gathered experts across several maternal immunisation initiatives—group B streptococcus, respiratory syncytial
virus, pertussis, and influenza. Finally, a global online survey prioritised the identified knowledge gaps on the basis of
expert opinion about their importance and relevance. Here we present the results of this worldwide landscape analysis
and discuss the identified research gaps.