Effect of phacoemulsification on facility of outflow
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Published version
Author(s)
Alaghband, Pouya
Beltran-Agulló, Laura
Galvis, Elizabeth Angela
Overby, Darryl R
Lim, Kin Sheng
Type
Journal Article
Abstract
PURPOSE: Phacoemulsification has been shown to reduce intraocular pressure (IOP). The mechanism of action is thought to be via increased trabecular outflow facility. However, studies on the relationship between phacoemulsification and outflow facility have been inconsistent. This study intended to examine the change in electronic Schiotz tonographic outflow facility (TOF) and IOP measurements following phacoemulsification. METHODS: Patients who were due to undergo a standard clear corneal incision phacoemulsification with intraocular lens (IOL) implantation, at St Thomas' Hospital, were invited to participate in this study. IOP was measured using Goldmann's applanation tonometer, and TOF was measured by electronic Schiotz tonography at baseline and at 3, 6 and 12 months postoperatively. RESULTS: Forty-one patients were recruited. Tonography data for 27 patients were reliable and available at all time points. Eleven cases had primary open angle glaucoma and cataract, while 16 patients had cataract only. Mean IOP reduced at every time point postoperatively significantly compared with baseline. TOF improved significantly after cataract extraction at all time points (baseline of 0.14±0.06 vs 0.18±0.09 at 3 months, P=0.02 and 0.20±0.09 at 6 months, P=0.003, 0.17±0.07 µL/min mmHg at 12 months, P=0.04). Five contralateral eyes of patients with cataracts only who did not have any intraocular surgery during the follow-up period were used as comparison. Their IOP and TOF did not change significantly at any postoperative visits. CONCLUSION: This is the first study using electronic Schiotz tonography with documented anterior chamber depth and gonioscopy after modern cataract surgery (CS) with phacoemulsification and IOL implantation. We demonstrated that phacoemulsification increases TOF and this fully accounts for the IOP reduction following CS. ISTCRN REGISTRATION NUMBER: ISRCTN04247738.
Date Issued
2018-10-22
Date Acceptance
2018-01-19
Citation
British Journal of Ophthalmology, 2018, 102, pp.1520-1526
ISSN
0007-1161
Publisher
BMJ Publishing Group
Start Page
1520
End Page
1526
Journal / Book Title
British Journal of Ophthalmology
Volume
102
Copyright Statement
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Sponsor
National Institutes of Health
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29654113
PII: bjophthalmol-2017-311548
Grant Number
203-1774
Subjects
Phacoemulsification
cataract surgery
glaucoma
outflow facility
tonography
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2018-04-13