Optical Coherence Tomography for detection of compound action potential in Xenopus Laevis sciatic nerve
File(s)
Accepted version
Author(s)
Troiani, F
Nikolic, K
Constandinou, TG
Type
Conference Paper
Abstract
Due to optical coherence tomography (OCT) high spatial and temporal resolution, this technique could be used to observe the quick changes in the refractive index that accompany action potential. In this study we explore
the use of time domain Optical Coherence Tomography (TD-OCT) for real time action potential detection in ex vivo Xenopus Laevis sciatic nerve. TD-OCT is the easiest and less expensive OCT technique and, if successful in
detecting real time action potential, it could be used for low cost monitoring devices. A theoretical investigation into the order of magnitude of the signals detected by a TD-OCT setup is provided by this work. A linear
dependence between the refractive index and the intensity changes is observed and the minimum SNR for which the setup could work is found to be SNR = 2 x
10⁴
.
the use of time domain Optical Coherence Tomography (TD-OCT) for real time action potential detection in ex vivo Xenopus Laevis sciatic nerve. TD-OCT is the easiest and less expensive OCT technique and, if successful in
detecting real time action potential, it could be used for low cost monitoring devices. A theoretical investigation into the order of magnitude of the signals detected by a TD-OCT setup is provided by this work. A linear
dependence between the refractive index and the intensity changes is observed and the minimum SNR for which the setup could work is found to be SNR = 2 x
10⁴
.
Date Issued
2016-03-18
Date Acceptance
2015-10-12
Citation
2016, 9690
Volume
9690
Copyright Statement
© 2016 SPIE (Society of Photo-Optical Instrumentation Engineers). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
EP/G070466/1
EP/K503733/1
BB/L018268/1
Source
SPIE Photonics West (BIOS)
Publication Status
Published
Start Date
2016-02-13
Coverage Spatial
San Francisco