A hidden Markov model approach to characterizing the photo-switching behavior of fluorophores
File(s)Supplementary_materials.pdf (1.14 MB) AOAS1240.pdf (747.5 KB)
Supporting information
Published version
Author(s)
Type
Journal Article
Abstract
Fluorescing molecules (fluorophores) that stochastically switch between photon-emitting and dark states underpin some of the most celebrated advancements in super-resolution microscopy. While this stochastic behavior has been heavily exploited, full characterization of the underlying models can potentially drive forward further imaging methodologies. Under the assumption that fluorophores move between fluorescing and dark states as continuous time Markov processes, the goal is to use a sequence of images to select a model and estimate the transition rates. We use a hidden Markov model to relate the observed discrete time signal to the hidden continuous time process. With imaging involving several repeat exposures of the fluorophore, we show the observed signal depends on both the current and past states of the hidden process, producing emission probabilities that depend on the transition rate parameters to be estimated. To tackle this unusual coupling of the transition and emission probabilities, we conceive transmission (transition-emission) matrices that capture all dependencies of the model. We provide a scheme of computing these matrices and adapt the forward-backward algorithm to compute a likelihood which is readily optimized to provide rate estimates. When confronted with several model proposals, combining this procedure with the Bayesian Information Criterion provides accurate model selection.
Date Issued
2019-09-01
Date Acceptance
2019-01-18
Citation
Annals of Applied Statistics, 2019, 13 (3), pp.1397-1429
ISSN
1932-6157
Publisher
Institute of Mathematical Statistics
Start Page
1397
End Page
1429
Journal / Book Title
Annals of Applied Statistics
Volume
13
Issue
3
Copyright Statement
©Institute of Mathematical Statistics, 2019
Subjects
Science & Technology
Physical Sciences
Statistics & Probability
Mathematics
Hidden Markov models
Markov processes
rate estimation
forward-backward algorithm
super-resolution microscopy
SINGLE-CHANNEL RECORD
APPARENT OPEN TIMES
PROBABILISTIC FUNCTIONS
SHUT TIMES
STATISTICAL-INFERENCE
MICROSCOPY
DISTRIBUTIONS
KINETICS
BINDING
PROBES
Hidden Markov models
Markov processes
forward-backward algorithm
rate estimation
super-resolution microscopy
0104 Statistics
1403 Econometrics
Statistics & Probability
Publication Status
Published
Date Publish Online
2019-10-17