Rhenium-based complexes and in vivo testing: A brief history
File(s)
Published version
Author(s)
Capper, Miles Samson
Rehkämper, Mark
Packman, Hollie
Type
Journal Article
Abstract
The success of metal‐based anticancer therapeutics in the treatment of cancer is best exemplified by cisplatin. Currently used in 32 / 78 cancer regimens, the use for metal‐based therapeutics has a clear role in cancer therapy. Despite this, metal‐based therapeutics are not without drawbacks, with issues such as toxic side effects and the development of resistance mechanisms. This has led to investigations of other metal‐based therapeutics such as auranofin, a gold‐based drug candidate as well as ruthenium‐based candidates, NAMI‐A, NKP‐1339 and TLD‐1433. All are undergoing current clinical trials. Another class of complexes under study are rhenium‐based; such complexes have undergone extensive in vitro testing but only seven have displayed antitumor in vivo activity which is a necessary step before entering clinical trials. This present review will document, chronologically, the rhenium‐based drug candidates that have undergone in vivo testing and the outlook for such complexes.
Date Issued
2020-08-03
Date Acceptance
2020-03-19
Citation
ChemBioChem, 2020, 21 (15), pp.2111-2115
ISSN
1439-4227
Publisher
Wiley
Start Page
2111
End Page
2115
Journal / Book Title
ChemBioChem
Volume
21
Issue
15
Copyright Statement
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
This is an open access article under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Natural Environment Research Council [2006-2012]
Identifier
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.202000117
Grant Number
grant number NE/S007415/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
Antitumor
chemotherapy
cisplatin
in vivo
rhenium
ANTICANCER ACTIVITY
ANTITUMOR-ACTIVITY
CISPLATIN
TUMOR
TECHNETIUM
COMPOUND
IMPACT
DNA
Antitumor
chemotherapy
cisplatin
in vivo
rhenium
0304 Medicinal and Biomolecular Chemistry
0601 Biochemistry and Cell Biology
Organic Chemistry
Publication Status
Published
Date Publish Online
2020-03-20