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Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
File(s)
Author(s)
Holmes, Holly E
Valentin, Rafael E
Jerneren, Fredrik
Loots, Celeste A de Jager
Refsum, Helga
Type
Journal Article
Abstract
Elevated plasma total homocysteine (tHcy) is associated with the development of Alzheimer's disease and other forms of dementia. In this study, we report the relationship between tHcy and epigenetic age in older adults with mild cognitive impairment from the VITACOG study. Epigenetic age and rate of aging (ROA) were assessed using various epigenetic clocks, including those developed by Horvath and Hannum, DNAmPhenoAge, and with a focus on Index, a new principal component-based epigenetic clock that, like DNAmPhenoAge, is trained to predict an individual's “PhenoAge.” We identified significant associations between tHcy levels and ROA, suggesting that hyperhomocysteinemic individuals were aging at a faster rate. Moreover, Index revealed a normalization of accelerated epigenetic aging in these individuals following treatment with tHcy-lowering B-vitamins. Our results indicate that elevated tHcy is a risk factor for accelerated epigenetic aging, and this can be ameliorated with B-vitamins. These findings have broad relevance for the sizable proportion of the worldwide population with elevated tHcy.
Date Issued
2024-10
Date Acceptance
2024-06-10
Citation
Aging Cell, 2024, 23 (10)
URI
URL
DOI
ISSN
1474-9718
Publisher
Wiley
Journal / Book Title
Aging Cell
Volume
23
Issue
10
Copyright Statement
© 2024 Elysium Health, Inc and The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.


This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://onlinelibrary.wiley.com/doi/10.1111/acel.14255
Subjects
AGE
BIOMARKER
B-vitamins
B-VITAMINS
Cell Biology
DEMENTIA
DNA methylation
epigenetic age
FOLATE
GENOME
Geriatrics & Gerontology
homocysteine
Life Sciences & Biomedicine
Science & Technology
Publication Status
Published
Article Number
e14255
Date Publish Online
2024-06-27