Fetal heart rate analysis in pregnancies complicated by gestational diabetes mellitus: a prospective multicentre observational study
Author(s)
Type
Journal Article
Abstract
Objective
Establish whether pregnancies complicated by gestational diabetes mellitus (GDM) are associated with a fetal cardiac phenotype that predisposes to arrhythmia; utilising measurements derived from non-invasive abdominal fetal ECG.
Design
Prospective observational study.
Setting
Three tertiary obstetric units, United Kingdom.
Population
Women aged ≥ 16 years with either GDM or uncomplicated pregnancy (control) who were > 20 weeks gestational age.
Methods
The MonicaAN24 non-invasive abdominal fetal ECG monitor was fitted for overnight recording.
Main Outcome Measure
Calculation of the fetal heart rate (FHR) and fetal heart rate variability (HRV) time domain metrics standard deviation of normal-to-normal intervals (SDNN), root mean square of successive differences (RMSSD) and the PR, QRS, QT intervals was performed. Groups were compared using linear regression models (stratified by sleep state) and adjusted for fetal sex and ethnicity.
Results
Ninety-six participants were included. For HRV in sleep state 1F, SDNN was higher for GDM than control participants 12.56 (10.45–16.62)ms versus 8.58 (5.83–9.73)ms [p = 0.01] [median (IQR)]. There were no differences in SDNN in sleep state 2F. No differences were identified in RMSSD in either sleep states or in the cardiac time intervals. We observed a negative correlation between HRV and body mass index/HbA1c and a positive correlation between FHR and body mass index/HbA1c in sleep states 1F/2F.
Conclusions
Alterations of HRV and FHR rate may be associated with a diagnosis of GDM, likely secondary to altered autonomic function in utero.
Establish whether pregnancies complicated by gestational diabetes mellitus (GDM) are associated with a fetal cardiac phenotype that predisposes to arrhythmia; utilising measurements derived from non-invasive abdominal fetal ECG.
Design
Prospective observational study.
Setting
Three tertiary obstetric units, United Kingdom.
Population
Women aged ≥ 16 years with either GDM or uncomplicated pregnancy (control) who were > 20 weeks gestational age.
Methods
The MonicaAN24 non-invasive abdominal fetal ECG monitor was fitted for overnight recording.
Main Outcome Measure
Calculation of the fetal heart rate (FHR) and fetal heart rate variability (HRV) time domain metrics standard deviation of normal-to-normal intervals (SDNN), root mean square of successive differences (RMSSD) and the PR, QRS, QT intervals was performed. Groups were compared using linear regression models (stratified by sleep state) and adjusted for fetal sex and ethnicity.
Results
Ninety-six participants were included. For HRV in sleep state 1F, SDNN was higher for GDM than control participants 12.56 (10.45–16.62)ms versus 8.58 (5.83–9.73)ms [p = 0.01] [median (IQR)]. There were no differences in SDNN in sleep state 2F. No differences were identified in RMSSD in either sleep states or in the cardiac time intervals. We observed a negative correlation between HRV and body mass index/HbA1c and a positive correlation between FHR and body mass index/HbA1c in sleep states 1F/2F.
Conclusions
Alterations of HRV and FHR rate may be associated with a diagnosis of GDM, likely secondary to altered autonomic function in utero.
Date Issued
2025-03
Date Acceptance
2024-11-05
Citation
BJOG: an International Journal of Obstetrics and Gynaecology, 2025, 132 (4), pp.473-482
ISSN
1470-0328
Publisher
Wiley
Start Page
473
End Page
482
Journal / Book Title
BJOG: an International Journal of Obstetrics and Gynaecology
Volume
132
Issue
4
Copyright Statement
© 2024 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39582422
Subjects
cardiac time intervals
fetal ECG
gestational diabetes
GLUCOSE
heart rate
heart rate variability
HYPERGLYCEMIA
INTERNATIONAL ASSOCIATION
Life Sciences & Biomedicine
MOTHERS
non-invasive fetal electrocardiography
Obstetrics & Gynecology
RATE-VARIABILITY
Science & Technology
TYPE-1
WOMEN
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2024-11-25