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Convergent and divergent mechanisms of sugar recognition across kingdoms
File(s)
Reprint.pdf (1.64 MB)
Published version
Author(s)
Drickamer, K
Taylor, ME
Type
Journal Article
Abstract
Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized.
Date Issued
2014-08-05
Date Acceptance
2014-08-05
Citation
Current Opinion in Structural Biology, 2014, 28, pp.14-22
URI
DOI
ISSN
0959-440X
Publisher
Elsevier
Start Page
14
End Page
22
Journal / Book Title
Current Opinion in Structural Biology
Volume
28
Copyright Statement
© 2014 The Authors. Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.
org/licenses/by/3.0/).
License URL
Publication Status
Published