Individually addressable multi-nanopores for single-molecule targeted operations
File(s)
Accepted version
Author(s)
Cadinu, Paolo
Kang, Minkyung
Paulose Nadappuram, Binoy
Ivanov, Alexandar
Edel, Joshua B
Type
Journal Article
Abstract
The fine-tuning of molecular transport is a ubiquitous problem of single-molecule methods. The latter is evident even in powerful single-molecule methods such as nanopore sensing, where the quest for resolving more detailed biomolecular features is often limited by insufficient control of the dynamics of individual molecules within the detection volume of the nanopore. In this work, we introduce and characterize a reconfigurable multi-nanopore architecture that enables additional channels to manipulate the dynamics of DNA molecules in a nanopore. We show that the fabrication process of this device, consisting of four adjacent, individually addressable nanopores located at the tip of a quartz nanopipette, is fast and highly reproducible. By individually tuning the electric field across each nanopore, these devices can operate in several unique cooperative detection modes that allow moving, sensing, and trapping DNA molecules with high efficiency and increased temporal resolution.
Date Issued
2020-02-13
Date Acceptance
2020-02-13
Citation
Nano Letters, 2020, 20 (3), pp.2012-2019
ISSN
1530-6984
Publisher
American Chemical Society (ACS)
Start Page
2012
End Page
2019
Journal / Book Title
Nano Letters
Volume
20
Issue
3
Copyright Statement
© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.9b05307
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Commission of the European Communities
Royal Society Of Chemistry
Identifier
https://pubs.acs.org/doi/10.1021/acs.nanolett.9b05307
Grant Number
EP/P011985/1
724300
BB/R022429/1
875525
600322/05
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
single-molecule sensing multi-nanopore architecture
biophysics
nanopore sensing
DNA
biophysics
multi-nanopore architecture
nanopore sensing
single-molecule sensing
Nanoscience & Nanotechnology
Publication Status
Published online
Article Number
acs.nanolett.9b05307
Date Publish Online
2020-02-13