Assisting continuous biomanufacturing through advanced control in downstream purification
File(s)
Accepted version
Author(s)
Papathanasiou, MM
Burnak, B
Katz, J
Shah, N
Pistikopoulos, EN
Type
Journal Article
Abstract
Aiming to significantly improve their processes and secure market share, monoclonal antibody (mAb) manufacturers seek innovative solutions that will yield improved production profiles. In that space, continuous manufacturing has been gaining increasing interest, promising more stable processes with lower operating costs. However, challenges in the operation and control of such processes arise mainly from the lack of appropriate process analytics tools that will provide the required measurements to guarantee product quality. Here we demonstrate a Process Systems Engineering approach for the design a novel control scheme for a semi-continuous purification process. The controllers are designed employing multi-parametric Model Predictive Control (mp-MPC) strategies and the successfully manage to: (a) follow the system periodicity, (b) respond to measured disturbances and (c) result in satisfactory yield and product purity. The proposed strategy is also compared to experimentally optimized profiles, yielding a satisfactory agreement.
Date Issued
2019-06-09
Date Acceptance
2019-03-07
Citation
Computers and Chemical Engineering, 2019, 125, pp.232-248
ISSN
0098-1354
Publisher
Elsevier B.V.
Start Page
232
End Page
248
Journal / Book Title
Computers and Chemical Engineering
Volume
125
Copyright Statement
© 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Grant Number
EP/P006485/1 - 000029212
EP/R013764/1
Subjects
0904 Chemical Engineering
0913 Mechanical Engineering
Chemical Engineering
Publication Status
Published
Date Publish Online
2019-03-15