Pre-RNA splicing in metabolic homeostasis and liver disease
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In this review, we showcase recent studies on the splicing and AS of key genes in metabolic pathways in the liver, the effect of metabolic signals on the spliceosome, and therapeutic intervention points based on RNA splicing.
Date Issued
2023-12-01
Date Acceptance
2023-08-07
Citation
Trends in Endocrinology and Metabolism, 2023, 34 (12), pp.823-837
ISSN
1043-2760
Publisher
Cell Press
Start Page
823
End Page
837
Journal / Book Title
Trends in Endocrinology and Metabolism
Volume
34
Issue
12
Copyright Statement
© 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37673766
PII: S1043-2760(23)00160-1
Subjects
Alternative Splicing
Homeostasis
Humans
Liver Diseases
RNA Splicing
alternative splicing
HCC
liver
metabolism
NAFLD/MAFLD
RNA
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-09-04