Hardwiring wire-less networks: spatially encoded GPCR signaling in endocrine systems
File(s)
Accepted version
Author(s)
Caengprasath, Natarin
Hanyaloglu, Aylin
Type
Journal Article
Abstract
The pivotal and diverse roles G protein-coupled receptors (GPCRs) play in physiology are matched by the increasingly complex signal systems they activate. Over the past decade, our models of GPCR signaling systems also include a vital role of location in controlling GPCR signaling, whereby plasma membrane, clathrin-associated structures and a diverse endomembrane network provide highly specialized signal platforms for this superfamily of receptors. The aim of this review is to highlight the recent developments in this fast-evolving field, with particular emphasis on endocrine-relevant GPCRs. We will also highlight studies that address the possibility of therapeutic intervention and how this fundamental cell biology can be translated to physiology/pathophysiology and therapeutic interventions.
Date Issued
2019-04-01
Date Acceptance
2018-12-14
Citation
Current Opinion in Cell Biology, 2019, 57, pp.77-82
ISSN
0955-0674
Publisher
Elsevier
Start Page
77
End Page
82
Journal / Book Title
Current Opinion in Cell Biology
Volume
57
Copyright Statement
© 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Society for Endocrinology
Grant Number
BB/N016947/1
WSCR_P70338
Subjects
0601 Biochemistry And Cell Biology
Developmental Biology
Publication Status
Published
Date Publish Online
2019-01-23