Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer
File(s)
Published version
Author(s)
Type
Conference Paper
Abstract
We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.
Editor(s)
Alfano, RR
Date Issued
2011-01-22
Date Acceptance
2011-01-01
Citation
Proceedings of SPIE, 2011, 7895
ISBN
9780819484321
ISSN
1996-756X
Publisher
Society of Photo-optical Instrumentation Engineers (SPIE)
Journal / Book Title
Proceedings of SPIE
Volume
7895
Copyright Statement
© 2011 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
http://spie.org/x648.html?product_id=875120
Grant Number
EP/F040202/1
Source
SPIE Photonics West 2011
Subjects
Science & Technology
Technology
Physical Sciences
Engineering, Biomedical
Optics
Engineering
fluorescence
fluorescence lifetime
diffuse reflectance
osteoarthritis
skin cancer
spectrometer
fibre probe
ELASTIN
CARCINOMA
MELANOMAS
COLLAGEN
Publication Status
Published
Start Date
2011-01-22
Finish Date
2011-01-27
Coverage Spatial
Moscone Center, San Francisco, California, USA