A federated cox model with non-proportional hazards
File(s)AAAI22_Workshop_FedSurv__Symplectic_.pdf (1.04 MB)
Accepted version
Author(s)
Zhang, Kai
Toni, Francesca
Williams, Matthew
Type
Conference Paper
Abstract
Recent research has shown the potential for neural networks
to improve upon classical survival models such as the Cox model, which
is widely used in clinical practice. Neural networks, however, typically
rely on data that are centrally available, whereas healthcare data are
frequently held in secure silos. We present a federated Cox model that
accommodates this data setting and also relaxes the proportional hazards
assumption, allowing time-varying covariate effects. In this latter respect,
our model does not require explicit specification of the time-varying ef-
fects, reducing upfront organisational costs compared to previous works.
We experiment with publicly available clinical datasets and demonstrate
that the federated model is able to perform as well as a standard model.
to improve upon classical survival models such as the Cox model, which
is widely used in clinical practice. Neural networks, however, typically
rely on data that are centrally available, whereas healthcare data are
frequently held in secure silos. We present a federated Cox model that
accommodates this data setting and also relaxes the proportional hazards
assumption, allowing time-varying covariate effects. In this latter respect,
our model does not require explicit specification of the time-varying ef-
fects, reducing upfront organisational costs compared to previous works.
We experiment with publicly available clinical datasets and demonstrate
that the federated model is able to perform as well as a standard model.
Date Issued
2022-11-29
Date Acceptance
2021-12-16
Citation
Studies in Computational Intelligence, 2022, pp.171-185
ISSN
1860-949X
Publisher
Springer
Start Page
171
End Page
185
Journal / Book Title
Studies in Computational Intelligence
Copyright Statement
Copyright © 2022 Springer-Verlag. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/978-3-031-14771-5_12
Identifier
https://link.springer.com/book/9783031147708
Source
The 6th International Workshop on Health Intelligence
Publication Status
Published
Start Date
2022-02-28
Finish Date
2022-03-01
Coverage Spatial
Vamcouver, Canada
Date Publish Online
2022-11-29