A great proportion of the existing architectural heritage, including historical and monumental constructions, is made of brick/block masonry. This material shows a strong anisotropic behaviour resulting from the specific arrangement of units and mortar joints, which renders the accurate imulation of the masonry response a complex task. In general, mesoscale modelling approaches provide realistic predictions due to the explicit representation of the masonry bond characteristics. However, these detailed models are very computationally demanding and mostly unsuitable for practical assessment of large structures. Macroscale models are more efficient, but they require complex calibration procedures to evaluate model material parameters. This paper presents an advanced continuum macroscale model based on a two-scale nonlinear description for masonry material which requires only simple calibration at structural scale. A continuum strain field is considered at the macroscale level, while a 3D distribution of embedded internal layers allows for the anisotropic mesoscale features at the local level. A damage-plasticity constitutive model is employed to mechanically characterise each internal layer using different material properties along the two main directions on the plane of the masonry panel and along its thickness. The accuracy of the proposed acroscale model is assessed considering the response of structural walls previously tested under in-plane and out-of-plane loading and modelled using the more refined mesoscale strategy. The results achieved confirm the significant potential and the ability of the proposed macroscale description for brick/block masonry to provide accurate and efficient response predictions under different monotonic and cyclic loading conditions.