Sustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infections
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Antibiotic-loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non-degradability results in a burst release of antibiotics and potential renal toxicity, necessitating additional surgeries for bead removal. There is a critical need for infection control materials that can deliver antibiotics effectively, maintain adequate mechanical strength, and degrade uniformly. This study introduces a gelatin–silica hybrid antibiotic carrier, characterized by covalent bonds between the gelatin and silica networks. The incorporation of the silica network enhances the compressive strength to 32.53 ± 2.4 MPa and ensures uniform degradation over 6 months, aligning with clinical timelines. Furthermore, the gelatin–silica hybrid can support up to 10 wt% antibiotic loading without compromising its properties, making it a promising candidate for next-generation infection control materials.
Date Issued
2024-12-02
Date Acceptance
2024-08-01
Citation
Advanced Functional Materials, 2024, 34 (49)
ISSN
1616-301X
Publisher
Wiley
Journal / Book Title
Advanced Functional Materials
Volume
34
Issue
49
Copyright Statement
Copyright © 2024 Wiley-VCH GmbH. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
http://dx.doi.org/10.1002/adfm.202409491
Publication Status
Published
Article Number
2409491
Date Publish Online
2024-08-28