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  5. High-fidelity diabetic retina fundus image synthesis from freestyle lesion maps
 
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High-fidelity diabetic retina fundus image synthesis from freestyle lesion maps
File(s)
boe-14-2-533.pdf (36.89 MB)
Published version
Author(s)
Hou, Benjamin
Type
Journal Article
Abstract
Retina fundus imaging for diagnosing diabetic retinopathy (DR) is an efficient and patient-friendly modality, where many high-resolution images can be easily obtained for accurate diagnosis. With the advancements of deep learning, data-driven models may facilitate the process of high-throughput diagnosis especially in areas with less availability of certified human experts. Many datasets of DR already exist for training learning-based models. However, most are often unbalanced, do not have a large enough sample count, or both. This paper proposes a two-stage pipeline for generating photo-realistic retinal fundus images based on either artificially generated or free-hand drawn semantic lesion maps. The first stage uses a conditional StyleGAN to generate synthetic lesion maps based on a DR severity grade. The second stage then uses GauGAN to convert the synthetic lesion maps into high resolution fundus images. We evaluate the photo-realism of generated images using the Fréchet inception distance (FID), and show the efficacy of our pipeline through downstream tasks, such as; dataset augmentation for automatic DR grading and lesion segmentation.
Date Issued
2023-01-04
Date Acceptance
2022-12-15
Citation
Biomedical Optics Express, 2023, 14 (2), pp.533-549
URI
http://hdl.handle.net/10044/1/102702
DOI
https://www.dx.doi.org/10.1364/BOE.477906
ISSN
2156-7085
Publisher
Optical Society of America
Start Page
533
End Page
549
Journal / Book Title
Biomedical Optics Express
Volume
14
Issue
2
Copyright Statement
© The Author(s) 2023. Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
License URL
https://creativecommons.org/licenses/by/4.0/
Publication Status
Published
Date Publish Online
2023-01-04
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