Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate.
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far.
Date Issued
2017-11-03
Date Acceptance
2017-09-04
Citation
Autoimmunity Reviews, 2017, 17 (1), pp.11-18
ISSN
1568-9972
Publisher
Elsevier
Start Page
11
End Page
18
Journal / Book Title
Autoimmunity Reviews
Volume
17
Issue
1
Copyright Statement
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
PII: S1568-9972(17)30276-8
Subjects
Immunosuppression
Lupus nephritis
Organ damage
Remission
Publication Status
Published