Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study
Author(s)
Dadhania, Seema
Pakzad-Shahabi, Lillie
Mistry, Sanjay
Williams, Matt
Type
Journal Article
Abstract
BACKGROUND: High-grade gliomas (HGG) account for 60-75% of all adult gliomas. The complexity of treatment, recovery and survivorship creates a need for novel monitoring approaches. Accurate assessment of physical function plays a vital role in clinical evaluation. Digital wearable tools could help us address unmet needs by offering unique advantages such as scale, cost and continuous real-world objective data. We present data from 42 patients enrolled into the BrainWear study. METHODS: An AX3 accelerometer was worn by patients from diagnosis or at recurrence. Age-, sex-matched UK Biobank control groups were chosen for comparison. RESULTS: 80% of data were categorised as high-quality demonstrating acceptability. Remote, passive monitoring identifies moderate activity reduces both during a course of radiotherapy (69 to 16 minutes/day) and at the time of progressive disease assessed by MRI (72 to 52 minutes/day). Mean acceleration (mg) and time spent walking daily (h/day) correlated positively with the global health quality of life and physical functioning scores and inversely with the fatigue score. Healthy controls walked on average 2.91h/day compared to 1.32h/day for the HGG group on weekdays and 0.91h/day on the weekend. The HGG cohort slept for longer on weekends (11.6h/day) than weekdays (11.2h/day) compared to healthy controls (8.9h/day). CONCLUSION: Wrist-worn accelerometers are acceptable and longitudinal studies feasible. HGG patients receiving a course of radiotherapy reduce their moderate activity by 4-fold and are at least half as active as healthy controls at baseline. Remote monitoring can provide a more informed and objective understanding of patient activity levels to help optimise health related quality of life (HRQoL) among a patient cohort with an extremely limited lifespan.
Date Issued
2023-05-24
Date Acceptance
2023-04-17
Citation
PLoS One, 2023, 18 (5), pp.1-21
ISSN
1932-6203
Publisher
Public Library of Science (PLoS)
Start Page
1
End Page
21
Journal / Book Title
PLoS One
Volume
18
Issue
5
Copyright Statement
© 2023 Dadhania et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37224155
PII: PONE-D-22-20706
Subjects
Accelerometry
Adult
Exercise
Glioma
Humans
Quality of Life
Walking
Publication Status
Published
Coverage Spatial
United States
Article Number
e0285399
Date Publish Online
2023-05-24