The application of 'omics' to pulmonary arterial hypertension
File(s)
Published version
Author(s)
Harbaum, Lars
Rhodes, Christopher J
Otero-Núñez, Pablo
Wharton, John
Wilkins, Martin R
Type
Journal Article
Abstract
Recent genome-wide analyses of rare and common sequence variations have brought greater clarity to the genetic architecture of pulmonary arterial hypertension and implicated novel genes in disease development. Transcriptional signatures have been reported in whole lung tissue, pulmonary vascular cells and peripheral circulating cells. High-throughput platforms for plasma proteomics and metabolomics have identified novel biomarkers associated with clinical outcomes and provided molecular instruments for risk assessment. There are methodological challenges to integrating these datasets, coupled to statistical power limitations inherent to the study of a rare disease, but the expectation is that this strategy will reveal novel druggable targets and biomarkers that will open the way to personalised medicine. Here we review the current state-of-the-art and future promise of "omics" in the field of translational medicine in pulmonary arterial hypertension.
Date Issued
2021-01-01
Date Acceptance
2020-02-18
Citation
British Journal of Pharmacology, 2021, 178 (1), pp.108-120
ISSN
0007-1188
Publisher
Wiley
Start Page
108
End Page
120
Journal / Book Title
British Journal of Pharmacology
Volume
178
Issue
1
Copyright Statement
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
British Heart Foundation
The Academy of Medical Sciences
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32201940
Grant Number
FS/15/59/31839
WMET_P76013
Subjects
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
PERIPHERAL-BLOOD CELLS
MENDELIAN RANDOMIZATION
MICROARRAY ANALYSIS
CONCISE GUIDE
EXPRESSION
PROTEIN
IDENTIFICATION
PATHWAY
DISEASE
PROLIFERATION
Pharmacology & Pharmacy
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-03-22