Respiratory microbiome and epithelial interactions shape immunity in the lungs
File(s)
OA Location
Author(s)
Invernizzi, Rachele
Lloyd, Clare M
Molyneaux, Philip L
Type
Journal Article
Abstract
The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly recognised as active effectors of microbial defence, contributing to both innate and adaptive immune function in the lower respiratory tract. These cells express an ample repertoire of pattern-recognition receptors with specificity for conserved microbial and host motifs. Modern molecular techniques have uncovered the complexity of the lower respiratory tract microbiome. The interaction between the microbiota and the airway epithelium is key to understanding how stable immune homeostasis is maintained. Loss of epithelial integrity following exposure to infection can result in the onset of inflammation in susceptible individuals and may culminate in lung disease. Here we discuss the current knowledge regarding the molecular and cellular mechanisms by which the pulmonary epithelium interacts with the lung microbiome in shaping immunity in the lung. Specifically, we focus on the interactions between the lung microbiome and the cells of the conducting airways in modulating immune cell regulation and how defects in barrier structure and function may culminate in lung disease. Understanding these interactions is fundamental in the search for more effective therapies for respiratory diseases.
Date Issued
2020-06-01
Date Acceptance
2020-03-01
Citation
Immunology, 2020, 160 (2), pp.171-182
ISSN
0019-2805
Publisher
Wiley
Start Page
171
End Page
182
Journal / Book Title
Immunology
Volume
160
Issue
2
Copyright Statement
© 2020 The Authors.Immunologypublished by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
The Royal Society
Rosetrees Trust
Action for Pulmonary Fibrosis
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32196653
Grant Number
RSG/R1/180264
A2172
n/a
Subjects
immunity
lungs
mucosal immunology; respiratory epithelium
respiratory microbiome
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-03-20