Dietary patterns and risk of colorectal cancer: a factor analysis in Uruguay
Author(s)
Type
Journal Article
Abstract
In the time period 1996-2004, a case-control study of colorectal cancer was conducted in Montevideo, Uruguay.
The study included 610 cases and 1,220 controls, frequency matched for age, sex, and residence. All cases were newly diagnosed and microscopically confirmed and controls were drawn from the same hospitals. Controls
were submitted to factor analysis (principal components method) and 4 dietary patterns for men (prudent,
traditional, Western, drinker) and 3 for women (prudent, Western, drinker) were retained. These were rotated
and normalized by the Kaiser method. Scores were applied to all participants (cases and controls) and odds
ratios were estimated by logistic regression and polynomial regression. The Western pattern showed an OR of 2.62 (95 % CI 1.36-5.08) for colon cancer among men, and women displayed a similar increase in risk. However,
rectal cancer was not associated with this diet, rather being inversely associated with the prudent and traditional
patterns among men (OR 0.49, 95 % CI 0.28-0.57 for the traditional pattern). In conclusion, whereas the Western
pattern was directly associated with colon cancer, the prudent pattern was strongly protective for rectal cancer.
The study included 610 cases and 1,220 controls, frequency matched for age, sex, and residence. All cases were newly diagnosed and microscopically confirmed and controls were drawn from the same hospitals. Controls
were submitted to factor analysis (principal components method) and 4 dietary patterns for men (prudent,
traditional, Western, drinker) and 3 for women (prudent, Western, drinker) were retained. These were rotated
and normalized by the Kaiser method. Scores were applied to all participants (cases and controls) and odds
ratios were estimated by logistic regression and polynomial regression. The Western pattern showed an OR of 2.62 (95 % CI 1.36-5.08) for colon cancer among men, and women displayed a similar increase in risk. However,
rectal cancer was not associated with this diet, rather being inversely associated with the prudent and traditional
patterns among men (OR 0.49, 95 % CI 0.28-0.57 for the traditional pattern). In conclusion, whereas the Western
pattern was directly associated with colon cancer, the prudent pattern was strongly protective for rectal cancer.
Date Issued
2011-03-01
Date Acceptance
2011-03-01
Citation
Asian Pacific Journal of Cancer Prevention, 2011, 12 (3), pp.753-759
ISSN
1513-7368
Publisher
West Asia Organization for Cancer Prevention
Start Page
753
End Page
759
Journal / Book Title
Asian Pacific Journal of Cancer Prevention
Volume
12
Issue
3
Copyright Statement
Asia Pacific Journal of Cancer Prevention is under the terms of the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit, and adapt the published work, provided the original work and source are appropriately cited.
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293173100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
COLON-CANCER
Colorectal cancer
CONSUMPTION
dietary patterns
factor analysis
HETEROCYCLIC AMINES
INDEX
Life Sciences & Biomedicine
Oncology
principal components
RECTAL-CANCER
Science & Technology
Publication Status
Published
Coverage Spatial
Thailand