Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia
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Published version
Author(s)
Type
Journal Article
Abstract
Here we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.
Date Issued
2020-12-17
Date Acceptance
2020-12-16
Citation
eLife, 2020, 9 (1)
ISSN
2050-084X
Publisher
eLife Sciences Publications Ltd
Journal / Book Title
eLife
Volume
9
Issue
1
Copyright Statement
Copyright Gregorova et al.
This article is distributed under
the terms of the Creative
Commons Attribution License,
which permits unrestricted use
and redistribution provided that
the original author and source are
credited.
This article is distributed under
the terms of the Creative
Commons Attribution License,
which permits unrestricted use
and redistribution provided that
the original author and source are
credited.
License URL
Sponsor
Welton Foundation
National Institutes of Health
Biotechnology and Biological Sciences Research Council (BBSRC)
Wellcome Trust
Versus Arthritis
Commission of the European Communities
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33331820
PII: e63430
Grant Number
N/A
HHSN272200900046C
BB/H005439/1
100046/Z/12/Z
21135
860325
Subjects
human
infectious disease
microbiology
Publication Status
Published online
Coverage Spatial
England
Date Publish Online
2020-12-17