Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
Date Issued
2016-10-18
Date Acceptance
2016-09-13
Citation
Chemical Communications, 2016, 52 (81), pp.12104-12107
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
12104
End Page
12107
Journal / Book Title
Chemical Communications
Volume
52
Issue
81
Copyright Statement
©The Royal Society of Chemistry 2016.
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000385156700022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
BB/K017292/1
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
FACIAL AMPHIPHILES
DETERGENT
CRYSTALLIZATION
TRANSPORT
RECEPTOR
CRYSTALLOGRAPHY
SOLUBILIZATION
SURFACTANTS
EXPRESSION
INSIGHTS
Publication Status
Published
Date Publish Online
2016-09-13