Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development
Author(s)
Type
Journal Article
Abstract
The 2015–16 Zika virus epidemic in the Americas drew global attention to Zika virus infection as a cause of microcephaly and Guillain–Barré syndrome. The epidemic highlighted the urgent need for preventive measures, including vaccines and monoclonal antibodies (mAbs). However, nearly 9 years later, no licensed Zika virus vaccines or mAbs are available, leaving the world's populations unprotected from ongoing disease transmission and future epidemics. The current low Zika virus incidence and unpredictability of future outbreaks complicates prospects for evaluation, licensure, and commercial viability of Zika virus vaccines and mAbs. We conducted an extensive review of Zika virus vaccines and mAbs in development, identifying 16 vaccines in phase 1 or phase 2 trials and three mAbs in phase 1 trials, and convened a 2-day meeting of 130 global Zika virus experts to discuss research priorities to advance their development. This Series paper summarises a priority research agenda to address key knowledge gaps and accelerate the licensure of Zika virus vaccines and mAbs for global use.
Date Issued
2025-07-01
Date Acceptance
2025-02-01
Citation
The Lancet Infectious Diseases, 2025, 25 (7), pp.e402-e415
ISSN
1473-3099
Publisher
Elsevier
Start Page
e402
End Page
e415
Journal / Book Title
The Lancet Infectious Diseases
Volume
25
Issue
7
Copyright Statement
Copyright © 2024 Elsevier Ltd. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40024262
PII: S1473-3099(24)00750-3
Subjects
CANDIDATE
DOUBLE-BLIND
HEALTHY-ADULTS
IMMUNOGENICITY
INFECTION
Infectious Diseases
Life Sciences & Biomedicine
PHASE-1
PROTECTION
REPLICATION
SAFETY
Science & Technology
VACCINATION
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2025-02-27