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MECHANISMS IN ENDOCRINOLOGY The sexually dimorphic role of androgens in human metabolic disease
File(s)
eje-17-0124.pdf (1.89 MB)
Published version
Author(s)
Schiffer, Lina
Kempegowda, Punith
Arlt, Wiebke
O'Reilly, Michael W
Type
Journal Article
Abstract
Female androgen excess and male androgen deficiency manifest with an overlapping adverse metabolic phenotype, including abdominal obesity, insulin resistance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and an increased risk of cardiovascular disease. Here, we review the impact of androgens on metabolic target tissues in an attempt to unravel the complex mechanistic links with metabolic dysfunction; we also evaluate clinical studies examining the associations between metabolic disease and disorders of androgen metabolism in men and women. We conceptualise that an equilibrium between androgen effects on adipose tissue and skeletal muscle underpins the metabolic phenotype observed in female androgen excess and male androgen deficiency. Androgens induce adipose tissue dysfunction, with effects on lipid metabolism, insulin resistance and fat mass expansion, while anabolic effects on skeletal muscle may confer metabolic benefits. We hypothesise that serum androgen concentrations observed in female androgen excess and male hypogonadism are metabolically disadvantageous, promoting adipose and liver lipid accumulation, central fat mass expansion and insulin resistance.
Date Issued
2017-09-01
Date Acceptance
2017-05-03
Citation
European Journal of Endocrinology (EJE), 2017, 177 (3), pp.R125-R143
URI
URL
DOI
ISSN
0804-4643
Publisher
Oxford University Press
Start Page
R125
End Page
R143
Journal / Book Title
European Journal of Endocrinology (EJE)
Volume
177
Issue
3
Copyright Statement
© 2017 The authors Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/28566439
PII: EJE-17-0124
Subjects
BODY-FAT DISTRIBUTION
CONGENITAL ADRENAL-HYPERPLASIA
CORONARY-ARTERY-DISEASE
Endocrinology & Metabolism
IMPAIRED GLUCOSE-TOLERANCE
INCREASED 5-ALPHA-REDUCTASE ACTIVITY
Life Sciences & Biomedicine
POLYCYSTIC-OVARY-SYNDROME
Science & Technology
SEX HORMONE-TREATMENT
SUBCUTANEOUS ADIPOSE-TISSUE
TESTOSTERONE REPLACEMENT THERAPY
TYPE-2 DIABETES-MELLITUS
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2017-09-01