Takotsubo syndrome: aetiology, presentation and treatment.
File(s)
Accepted version
Author(s)
Kato, Ken
Lyon, Alexander R
Ghadri, Jelena-R
Templin, Christian
Type
Journal Article
Abstract
In the clinical setting, Takotsubo syndrome (TTS) is one of the most important diseases that must be accurately differentiated from acute coronary syndrome (ACS) to enable appropriate follow-up and medical management. The prevalence of TTS is estimated to be approximately 2%–3% in all patients presenting with suspected ACS.1 However, it may be underestimated because knowledge of diagnostic criteria is often incomplete, such as the possible coexistence of coronary artery disease (CAD). According to the widely used Mayo Clinic Diagnostic Criteria modified in 2008, incidental obstructive CAD not related to the wall motion abnormality may be an inclusion criterion for the diagnosis of TTS. However, this fact has been cited only as a footnote in a paper by Prasad and colleagues.2 In addition, atypical variants are not very well recognised by physicians, which may contribute to the underestimation of TTS.3 In 2015, the International Takotsubo Registry (www.takotsubo-registry.com), which is the largest systematic database on patients suffering from TTS, revealed novel data pertaining to TTS, which aided to the understanding of this enigmatic disease.4 This review summarises current knowledge on the aetiology, presentation and treatment of TTS.
Date Issued
2017-09-01
Date Acceptance
2017-08-01
Citation
Heart, 2017, 103 (18), pp.1461-1469
ISSN
1355-6037
Publisher
BMJ Publishing Group
Start Page
1461
End Page
1469
Journal / Book Title
Heart
Volume
103
Issue
18
Copyright Statement
© 2017 Article author(s) (or their employer(s) unless otherwise stated in
the text of the article). All rights reserved. No commercial use
is permitted unless otherwise expressly granted. This article has been accepted for publication in Heart following peer review. The definitive copyedited, typeset version Kato K, Lyon AR, Ghadri J, et al
Takotsubo syndrome: aetiology, presentation and treatment
Heart 2017;103:1461-1469 is available online at: https://dx.doi.org/10.1136/heartjnl-2016-309783
the text of the article). All rights reserved. No commercial use
is permitted unless otherwise expressly granted. This article has been accepted for publication in Heart following peer review. The definitive copyedited, typeset version Kato K, Lyon AR, Ghadri J, et al
Takotsubo syndrome: aetiology, presentation and treatment
Heart 2017;103:1461-1469 is available online at: https://dx.doi.org/10.1136/heartjnl-2016-309783
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/28839096
PII: heartjnl-2016-309783
Subjects
aetiology
broken heart syndrome
clinical presentation
takotsubo syndrome
treatment
Animals
Behavior Therapy
Cardiovascular Agents
Diagnostic Imaging
Electrocardiography
Humans
Stress, Psychological
Takotsubo Cardiomyopathy
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2017-08-24