Arterial stiffness is inversely related to plasma adiponectin levels in young normotensive patients with type 1 diabetes
Author(s)
Tsiakou, Afroditi
Liatis, Stavros
Alexiadou, Kleopatra
Diakoumopoulou, Evanthia
Makrilakis, Konstantinos
Type
Journal Article
Abstract
OBJECTIVE
This study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS
Participants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmunoassay.
RESULTS
Data from 80 patients (age 27.1 ± 6.1 years, BMI 24.2 ± 3.1 kg/m2, HbA1c 7.5 ± 1.6%, 39 men, adiponectin 13.9 ± 6.7 μg/mL, and PWV 5.6 ± 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = −0.291, P = 0.009) and waist circumference (r = −0.427, P < 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6% of its variance.
CONCLUSIONS
Arterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications.
This study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS
Participants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmunoassay.
RESULTS
Data from 80 patients (age 27.1 ± 6.1 years, BMI 24.2 ± 3.1 kg/m2, HbA1c 7.5 ± 1.6%, 39 men, adiponectin 13.9 ± 6.7 μg/mL, and PWV 5.6 ± 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = −0.291, P = 0.009) and waist circumference (r = −0.427, P < 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6% of its variance.
CONCLUSIONS
Arterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications.
Date Issued
2013-03-01
Date Acceptance
2012-08-08
Citation
Diabetes Care, 2013, 36 (3), pp.734-736
ISSN
0149-5992
Publisher
American Diabetes Association
Start Page
734
End Page
736
Journal / Book Title
Diabetes Care
Volume
36
Issue
3
Copyright Statement
© 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly
cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000315928700049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Publication Status
Published
Date Publish Online
2013-02-13