Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways
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Published version
Author(s)
Rodero Gomez, Cristobal
Baptiste, Tiffany MG
Barrows, Rosie K
Lewalle, Alexandre
Niederer, Steven A
Type
Journal Article
Abstract
Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link microscale physiology to whole-organ function. However, cardiac biomechanics models still have limited clinical translation. In this review, we provide a picture of cardiac mechanics models, focusing on their clinical translation. We review the main experimental and clinical data used in cardiac models, as well as the steps followed in the literature to generate anatomical meshes ready for simulations. We describe the main models in active and passive mechanics and the different lumped parameter models to represent the circulatory system. Lastly, we provide a summary of the state-of-the-art in terms of ventricular, atrial, and four-chamber cardiac biomechanics models. We discuss the steps that may facilitate clinical translation of the biomechanics models we describe. A well-established software to simulate cardiac biomechanics is lacking, with all available platforms involving different levels of documentation, learning curves, accessibility, and cost. Furthermore, there is no regulatory framework that clearly outlines the verification and validation requirements a model has to satisfy in order to be reliably used in applications. Finally, better integration with increasingly rich clinical and/or experimental datasets as well as machine learning techniques to reduce computational costs might increase model reliability at feasible resources. Cardiac biomechanics models provide excellent opportunities to be integrated into clinical workflows, but more refinement and careful validation against clinical data are needed to improve their credibility. In addition, in each context of use, model complexity must be balanced with the associated high computational cost of running these models.
Date Issued
2023-11-14
Date Acceptance
2023-11-02
Citation
Frontiers in Physics, 2023, 11
ISSN
2296-424X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Physics
Volume
11
Copyright Statement
Copyright © 2023 Rodero, Baptiste, Barrows, Lewalle, Niederer and Strocchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.frontiersin.org/articles/10.3389/fphy.2023.1306210/full
Publication Status
Published
Article Number
1306210
Date Publish Online
2023-11-14