The potential for over diagnosis of Paget’s disease of bone using macroscopic analysis
File(s)Garnett & Lewis 2022.pdf (7.02 MB)
Published version
Author(s)
Garnett, EM
Lewis, ME
Type
Journal Article
Abstract
Objective
This study explores the validity of Paget’s disease of bone (PDB) reported in unpublished skeletal reports, based on macroscopic analysis alone.
Materials
The high prevalence of ‘suspected’ Paget’s disease (10.7%) in an early modern sample from St John’s the Evangelist Church in Redhill, Surrey is reassessed.
Methods
Signs of PDB were examined in 53 well-preserved adults aged 35 + years using macroscopic, radiographic and histological techniques.
Results
Macroscopic features of PDB were identified in 8 individuals (15%), with 5 individuals later rejected using radiography. Two individuals showed classic radiographic features of PDB, with a third presenting possible features in radiography (5.7%). These three cases were confirmed by histological analysis.
Conclusions
PDB should not be suggested as a single diagnosis in cases of bone hypertrophy without confirmation using radiography.
Significance
The growing popularity of ‘big data’ projects and limited collections access means that unpublished cases of PDB are often included in large scale analyses, impacting our understanding of the evolution of this disease. Using macroscopic analysis alone leads to overdiagnosis. Histological analysis is unnecessary when radiographic features are present, but provides a useful diagnostic step in long bones in advanced cases of PBD.
Limitations
The radiographic sample in this study was limited to three individuals.
Suggestions for further research
The conclusion that radiography alone can be used to identify PDB in archaeological cases merits further research on a larger number of cases.
This study explores the validity of Paget’s disease of bone (PDB) reported in unpublished skeletal reports, based on macroscopic analysis alone.
Materials
The high prevalence of ‘suspected’ Paget’s disease (10.7%) in an early modern sample from St John’s the Evangelist Church in Redhill, Surrey is reassessed.
Methods
Signs of PDB were examined in 53 well-preserved adults aged 35 + years using macroscopic, radiographic and histological techniques.
Results
Macroscopic features of PDB were identified in 8 individuals (15%), with 5 individuals later rejected using radiography. Two individuals showed classic radiographic features of PDB, with a third presenting possible features in radiography (5.7%). These three cases were confirmed by histological analysis.
Conclusions
PDB should not be suggested as a single diagnosis in cases of bone hypertrophy without confirmation using radiography.
Significance
The growing popularity of ‘big data’ projects and limited collections access means that unpublished cases of PDB are often included in large scale analyses, impacting our understanding of the evolution of this disease. Using macroscopic analysis alone leads to overdiagnosis. Histological analysis is unnecessary when radiographic features are present, but provides a useful diagnostic step in long bones in advanced cases of PBD.
Limitations
The radiographic sample in this study was limited to three individuals.
Suggestions for further research
The conclusion that radiography alone can be used to identify PDB in archaeological cases merits further research on a larger number of cases.
Date Issued
2022-09
Date Acceptance
2022-07-01
Citation
International Journal of Paleopathology, 2022, 38, pp.55-63
ISSN
1879-9817
Publisher
Elsevier BV
Start Page
55
End Page
63
Journal / Book Title
International Journal of Paleopathology
Volume
38
Copyright Statement
© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.sciencedirect.com/science/article/pii/S1879981722000377?via%3Dihub
Subjects
1601 Anthropology
2101 Archaeology
Publication Status
Published
Date Publish Online
2022-07-08