MiRNAs in tuberculosis: Their decisive role in the fate of TB
File(s)
Author(s)
Alipoor, Shamila D
Adcock, Ian M
Tabarsi, Payam
Folkerts, Gert
Mortaz, Esmaeil
Type
Journal Article
Abstract
Tuberculosis (TB) is one of the most lethal global infectious diseases. Despite the availability of much higher levels of technology in health and medicine, tuberculosis still remains a serious global health problem. Mycobacterium tuberculosis has the capacity for prolonged survival inside macrophages by exploiting host metabolic and energy pathways and perturbing autophagy and apoptosis of infected cells. The mechanism(s) underlying this process are not completely understood but evidence suggests that mycobacteria subvert the host miRNA network to enable mycobacterial survival. We present here a comprehensive review on the role of miRNAs in TB immune escape mechanisms and the potential for miRNA-based TB therapeutics. Further validation studies are required to (i) elucidate the precise effect of TB on host miRNAs, (ii) determine the inhibition of mycobacterial burden using miRNA-based therapies and (iii) identify novel miRNA biomarkers that may prove useful in TB diagnosis and treatment monitoring.
Date Issued
2020-11-05
Date Acceptance
2020-08-28
Citation
European Journal of Pharmacology, 2020, 886
ISSN
0376-6357
Publisher
Elsevier
Journal / Book Title
European Journal of Pharmacology
Volume
886
Copyright Statement
© 2020 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32919937
PII: S0014-2999(20)30621-X
Subjects
Apoptosis
Autophagy
Tuberculosis
miRNA
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
ARTN 173529
Date Publish Online
2020-09-10