Pregnancy in chronic kidney disease and kidney transplantation
File(s)KI review 2016 Pregnancy submitted version.pdf (794.55 KB)
Accepted version
Author(s)
Webster, P
Lightstone, L
McKay, DB
Josephson, MA
Type
Journal Article
Abstract
Chronic kidney disease (CKD) affects up to 6% of women of childbearing age in high income countries, and is estimated to affect 3% of pregnant women. Advanced renal dysfunction, proteinuria, hypertension, and poorly controlled underlying primary renal disease are all significant risks for adverse maternal, fetal, and renal outcomes. In order to achieve the best outcomes, it is therefore of paramount importance that these pregnancies are planned, where possible, to allow the opportunity to counsel women and their partners in advance and to optimize these risks. These pregnancies should be deemed high risk and they require close antenatal monitoring from an expert multidisciplinary team. We discuss the effect of pregnancy on CKD, and also current guidelines and literature with specific reference to transplantation, autoimmune disease, and medication use in pregnancy. We also discuss the benefits of prepregnancy counseling and give practical recommendations to advise pregnant women with renal disease.
Date Issued
2017-02-13
Date Acceptance
2016-10-06
Citation
Kidney International, 2017, 91 (5), pp.1047-1056
ISSN
1523-1755
Publisher
Elsevier
Start Page
1047
End Page
1056
Journal / Book Title
Kidney International
Volume
91
Issue
5
Copyright Statement
© 2016, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400541000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
acute rejection
chronic kidney disease
kidney transplantation
outcomes
pregnancy
SYSTEMIC-LUPUS-ERYTHEMATOSUS
NOCTURNAL HOME HEMODIALYSIS
STAGE RENAL-DISEASE
IMMUNOSUPPRESSIVE DRUGS
CONGENITAL-MALFORMATIONS
HYPERTENSIVE PREGNANCY
PLACENTAL-TRANSFER
BLOOD-PRESSURE
OUTCOMES
WOMEN
Publication Status
Published