The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis
Author(s)
Reglinski, Mark
Sriskandan, Shiranee
Type
Journal Article
Abstract
Streptococcus pyogenes (group A streptococcus, GAS) is responsible for a wide range of pathologies ranging from mild pharyngitis and impetigo to severe invasive soft tissue infections. Despite the continuing susceptibility of the bacterium to β-lactam antibiotics there has been an unexplained resurgence in the prevalence of invasive GAS infection over the past 30 years. Of particular importance was the emergence of a GAS-associated sepsis syndrome that is analogous to the systemic toxicosis associated with TSST-1 producing strains of Staphylococcus aureus. Despite being recognized for over 20 years, the etiology of GAS associated sepsis and the streptococcal toxic shock syndrome remains poorly understood. Here we review the virulence factors that contribute to the etiology of GAS associated sepsis with a particular focus on coagulation system interactions and the role of the superantigens in the development of streptococcal toxic shock syndrome.
Date Issued
2014-01-01
Date Acceptance
2013-09-06
Citation
Virulence, 2014, 5 (1), pp.127-136
ISSN
2150-5594
Publisher
Taylor & Francis Online
Start Page
127
End Page
136
Journal / Book Title
Virulence
Volume
5
Issue
1
Copyright Statement
© 2014 Landes Bioscience
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
License URL
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330573000013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
G0800777
G0800777
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
group A streptococcus
sepsis
toxic shock syndrome
superantigen
STSS
TOXIC-SHOCK-SYNDROME
HYALURONIC-ACID CAPSULE
MITOGENIC EXOTOXIN-Z
HLA CLASS-II
ORGAN DYSFUNCTION SYNDROME
SOFT-TISSUE INFECTION
VON-WILLEBRAND-FACTOR
INFLAMMATION IN-VIVO
MHC CLASS-II
PYROGENIC EXOTOXIN
Publication Status
Published
Date Publish Online
2013-10-09