MALT lymphoma arising on a background of reactive pulmonary lymphoid hyperplasia in a patient with Systemic Lupus Erythematosus.
File(s)
Author(s)
Laggner, U
Khiroya, R
Wotherspoon, AC
Desai, SR
Nicholson, AG
Type
Journal Article
Abstract
Interstitial lung diseases are not infrequently complicated by development of malignancies and whilst most cases are carcinomas, rare cases of lymphoma have been reported,(1 2) these being diffuse large B-cell lymphomas and often associated with connective tissue disorders (CTDs). Reactive pulmonary lymphoid hyperplasia (RPLH), typically in the form of lymphoid interstitial pneumonia (LIP) often arises in patients with CTDs and only rarely shows malignant transformation,(3) with many of the early putative cases of transformation to MALT (mucosa-associated lymphoid tissue) lymphoma from LIP being lymphoma 'de novo'.(4) Herein we present a case of pulmonary non-Hodgkin lymphoma of MALT origin arising on a background RPLH with coexistent amyloidosis, confirmed by immunohistochemical and clonality studies. A 57 year old Caucasian female presented with chest pain and breathlessness at rest. She also described intermittent cough with small amounts of sputum, intermittent sweats, fatigue and joint pain in hands, feet, wrists, knees. She was known to have systemic lupus erythematosus (SLE) and SLE-related antiphospholipid syndrome for which she received immunosuppressive therapy including mycophenolate, prednisolone and hydroxychloroquin. This article is protected by copyright. All rights reserved.
Date Issued
2017-09-25
Date Acceptance
2017-09-25
Citation
Histopathology, 2017, 72 (4), pp.704-706
ISSN
0309-0167
Publisher
Wiley
Start Page
704
End Page
706
Journal / Book Title
Histopathology
Volume
72
Issue
4
Copyright Statement
This is the peer reviewed version of the following article: Laggner, U., Khiroya, R., Wotherspoon, A. C., Desai, S. R. and Nicholson, A. G. (), MALT lymphoma arising on a background of reactive pulmonary lymphoid hyperplasia in a patient with Systemic Lupus Erythematosus. Histopathology. Accepted Author Manuscript. , which has been published in final form at https://dx.doi.org/10.1111/his.13407. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Subjects
MALT lymphoma
reactive pulmonary lymphoid hyperplasia
systemic lupus erythematosus
Publication Status
Published